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A total of 3 % of Lively material is excreted in urine as unchanged active material. Tapentadol is Furthermore metabolised to N-desmethyl tapentadol (thirteen %) by CYP2C9 and CYP2C19 also to hydroxy tapentadol (2 %) by CYP2D6, which might be further more metabolised by conjugation. As a result, Energetic compound metabolism mediated by cytochrome